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Research Project
Research Interest
I am interested in various fields of bioinformatics, including modeling large-scale proteomics data in biomarker discovery studies, analyzing CGH array/microarray with statistical methods, and studying biology pathway networks based on multiple types of data. I am also collaborating with scientists in Fred Hutchinson on a range of epidemiology studies.
Recent Projects
Sparse Partial Correlation Estimation
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Partial Correlation Estimation by Joint Sparse Regression Model
Technical Report 2007 (pdf)
Software: space (R Package)
CGH array data.
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CLAC (CLuter Along Chromosome) method for calling gains/losses for array CGH data.
Biostatistics Paper 2005, 6, 1 (pdf)
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Spatial smoothing and hot spot detection for CGH data using the Fused Lasso.
Biostatistics Paper 2007 (pdf)
Software: cghFLasso (R Package)
eQTL mapping.
- Controlling for False Positive Findings of Trans-Hubs in e-QTL Mapping.
LC-MS based Proteomics data.
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Normlization regarding non-random missing values in high-throughput mass spectrometry data.
PSB 2006 Proceeding paper (pdf)
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PETAL (Peptide ElemenT ALignment) method for chromatographic alignment of LC-MS data.
Biostatistics paper 2006 (pdf)
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SASPECT (Significant AnalysiS of PEptide CounTs) method for Significant anlaysis of comparative proteomics based on LC-MS/MS Experiments
Related Links
CPL home page (Martin McIntosh's informatic group)